Association of Guillain-Barre Syndrome and Lupus Nephritis, regarding a clinical case.

Abstract

^{Introduction: Systemic lupus erythematosus is a chronic, inflammatory, autoimmune, multisystem rheumatic disease. Its clinical presentation is insidious and variable, ranging from skin lesions to systemic disorders such as lupus nephritis and Guillain-Barré syndrome, which are of particular interest due to their frequency and severity.} 

^{Objective: To analyze the association between Guillain-Barré syndrome and lupus nephritis based on a clinical case.} 

^{Results: We present the case of a 48-year-old male patient with acute renal dysfunction, Guillain-Barré syndrome, and involvement of other organs. After several diagnostic suspicions, the diagnosis of systemic lupus erythematosus was confirmed based on internationally established diagnostic criteria. Novel due to the rare association of these entities as complications of lupus.}

^{Conclusions: In this case, Guillain-Barré syndrome was present in the clinical picture of lupus, despite being a fairly rare complication; in contrast to lupus nephritis, a severe manifestation with a high prevalence. The association between Guillain-Barré syndrome and lupus nephritis is unusual but relevant, linked to the immunological dysregulation. Its coexistence requires a multidisciplinary approach to optimize treatment and prevent irreversible organ damage. It is important to evaluate all patients with Guillain-Barré Syndrome to rule out Systemic Lupus Erythematosus as a possible etiology.}