METASTATIC MELANOMAIN A PATIENT WITH KIDNEY TRANSPLANT
Keywords:
melanoma; kidney transplant; immunotherapyAbstract
Abstract
Introduction: Melanomas are immunogenic tumors that increase their incidence and aggressiveness during immunosuppression in patients with solid organ transplants. Objective: We report the case of a patient with a kidney transplant and a history of melanoma with surgical and oncological treatment, with a torpid evolution, who died. Methods: All data were collected from the clinical history and clinical autopsy. Samples were taken from each organ and stained with hematoxylin-eosin for observation under the optical microscope. Results: A 49-year-old male patient with a history of: arterial hypertension, advanced chronic kidney disease, with a kidney transplant and melanoma diagnosed 3 years ago with lymph node infiltration, for which he received oncological treatment. He was admitted for anorexia, dyspepsia, vomiting, weakness and drowsiness. Physical examination revealed yellow and dry skin and mucosa, decreased breath sounds at both bases, tachycardic heart sounds, diffuse abdominal pain on palpation, clouded speech and reactive isochoric pupils, presence of adenopathy in the left axillary region and a tumor lesion in the posterior portion of the left shoulder. The patient's progress was unfavorable and he died. A clinical autopsy was performed, confirming multiple melanoma metastases. Conclusions: Patients with solid organ transplants with advanced stage melanoma have a low survival rate and a worse prognosis compared to the rest of the population. Since they are excluded from clinical trials, much remains to be investigated regarding oncological treatment. Keywords: melanoma; kidney transplant; immunotherapy
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Copyright (c) 2025 Leticia Rodríguez Leyva, Laura López Marín, Christian Leyva de la Torres, Yadira Iduarte
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