Influence of immunological variables of the living donor and recipient on graft function
Keywords:
living donor kidney transplant, immunological variables, Acute kidney injury, filter rates, antiHLA antibodiesAbstract
Introduction: post-transplant kidney graft function is highly influenced by various immunological variables that occur in both the donor and the recipient.
Objective: to establish a relationship between immunological variables of the living donor and graft function one year after the procedure.
Methods: An observational, descriptive, retrospective historical cohort study was carried out in patients benefiting from a KT from a living donor, treated at the Institute of Nephrology, during the period between January 2013 and December 2020. The study universe was 62 patients and the sample was 58, who met the established inclusion criteria. Variables such as age, sex, relationship, anti-HLA class I and anti-HLA class antibodies in the recipient, anti-EBV IgG class antibodies in the living donor and recipient, anti-CMV IgG class antibodies in the living donor and recipient, and glomerular filtration rate were evaluated.
Results: The group of siblings predominated with 31 subjects for 53.4%; followed by mothers with 16 subjects for 27.6%. The highest mean glomerular filtration rates were described for the combination anti-HLA-class I negative + anti-HLA-class II positive with a mean of 79,000 mL/min/m2. In relation to the presence of anti-EBV IgG class antibodies in living donor and recipient (IBL ELISA), the combinations with the highest means were D-/R+ followed by D+/R+.
Conclusions: the level of relationship in living donor kidney transplantation is a determining factor in clinical results and patient satisfaction.
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Copyright (c) 2025 Yaime emelda Navarro García, Cristian Leyva Torres, Francisco Gutiérrez García, Lianet Noa Fernández
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