Markers of kidney damage in pediatric patients convalescent from COVID-19
Keywords:
COVID-19, pediatric patients convalescent from COVID-19, kidney damage markersAbstract
Introduction: there is no evidence of kidney damage in pediatric patients convalescent from COVID-19 in the Cuban context.
Objective: to describe the presence of markers of kidney damage in pediatric patients convalescent from COVID-19.
Methods: an observational, descriptive, longitudinal and prospective study was carried out on 64 convalescent patients from COVID-19, treated at the "Dr. Luis Díaz Soto" Hospital, in the period June to July 2021. The variables to be analyzed were identified in a follow-up in two stages: upon admission and six months after hospital discharge. Measurements of markers of acute kidney injury and estimation of acute kidney injury were performed according to the 2012 KDIGO guidelines. Descriptive statisticians were used.
Results: patients aged 10 to 18 years (51.5%), female (55.9%) and white skin color (62.5%) predominated. The asymptomatic state prevailed (67.2%). The most frequent markers of kidney damage were elevated cystatin C at admission (37%), elevated creatinine (24%), and at six months of follow-up they had this marker (23.4%). Acute kidney injury was identified in three patients. Patients with normal kidney function without markers of kidney damage at admission or at six months stood out (53.1%).
Conclusions: only in a minority of patients was acute kidney injury evident. Heterogeneous manifestations were presented in the evolution of renal function and renal markers in the sample.
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References
Martínez J, Torres C, Orozco ED. Características, medidas de política pública y riesgos de la pandemia del Covid-19. México: Dirección General de Investigaciones Estratégicas; 2020 [acceso 20/04/2023]. Disponible en: http://bibliodigitalibd.senado.gob.mx/bitstream/handle/123456789/4816/Covid19%2
Wang T, Du Z, Zhu F, Cao Z, An Y, Gao Y, Jiang B. Comorbidities and multi-organ injuries in the treatment of COVID-19. Lancet [Internet]. 2020 [acceso 20/04/2023]; 395(10228):e52. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32171074/
Hong H, Wang Y, Chung HT, Chen CJ. Clinical characteristics of novel coronavirus disease 2019 (COVID-19) in newborns, infants and children. Pediatr Neonatol [Internet]. 2020 [acceso 20/04/2023].;61(2):131-132. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32199864/
Qiu H, Wu J, Hong L, Luo Y, Song Q, Chen D. Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study. Lancet Infect Dis [Internet]. 2020 [acceso 20/04/2023]; 20(6):689-696. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32220650/
Calvo C, Tagarro A, Otheo E, Epalza C. Actualización de la situación epidemiológica de la infección por SARS-CoV-2 en España. Comentarios a Las recomendaciones de manejo de la infección en pediatría. Anales Pediatria [Internet]. 2020 [acceso 08/12/2023];92(4):239-40. Disponible en: https://doi.org/10.1016/j.anpedi.2020.03.001
KDIGO. Clinical Practice Guideline for Adult Kidney Injury. Kidney International Supplements [Internet]. 2012 [acceso 20/04/2023]; 2 (1). Disponible en: https://kdigo.org/wp-content/uploads/2016/10/KDIGO-2012-AKI-Guideline-English.pdf
Fraga GM, Huertes B. Evaluación básica de la función renal en Pediatría. Protoc. Diagn. terap. Pediatr [Internet]. 2014 [acceso 10/03/2023]; 1: 21-35. Disponible en: https://www.aeped.es/sites/default/files/documentos/02_evaluacion_basica_fr.pdf
Martin SM, Meni Battaglia L, Ferraris J, Ramírez F, et al. Prevalencia de compromiso renal en pacientes pediátricos internados con enfermedad por coronavirus 2019: estudio multicéntrico. Arch Argent Pediatr [Internet]. 2022 [acceso 16/03/2023];120(5):310-316. Disponible en: https://www.sap.org.ar/docs/publicaciones/archivosarg/2022/v120n5a06.pdf
Ludvigsson JF. Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Acta Paediatr [Internet]. 2020 [acceso 10/05/2023].;109(6):1088-1095. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32202343/
Montaño VE, Miranda MG. Actualización del manejo clínico de COVID-19 en pediatría: a un año de pandemia. Rev Mex Pediatr [Internet]. 2021 [acceso 10/05/2023]; 88(1): 31-45. Disponible en: https://dx.doi.org/10.35366/99417
Carballal M, Balaguer JV, García C, Morillo B, Domínguez B, Jimenez R, et al. Expresión clínica de la COVID-19 en pediatría de atención primaria: estudio COVIDPAP. An Pediatr (Barc) [ Internet]. 2022 [10/05/2023];97(1):48-58. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057975/
Acosta J, Pérez M, Rodríguez M, Morales A. COVID-19 en pediatría: aspectos clínicos, epidemiológicos, inmunopatogenia, diágnóstico y tratamiento. Rev Cubana Pediatr [Internet]. 2020 [10/05/2023] ; 92( Suppl 1 ): e1152. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S003475312020000500007&lng=es
Mengana E, Pérez Y, Portuondo D, Domínguez D, Álvarez R, Rodríguez Y. Caracterización clínico-epidemiológica de los niños positivos a SARS-COV-2 en Santiago de Cuba. Revista Cubana de Pediatría [Internet]. 2020 Jul [acceso 10/05/2023];92(Supl):e1177. Disponible en: http://www.revpediatria.sld.cu/index.php/ped/article/view/1177
Riyuzo MC, Silveira LV, Macedo CS, Fioretto JR. Predictive factors of mortality in pediatric patients with acute renal injury associated with sepsis. J Pediatr (Rio J) [Internet]. 2017 [ acceso 10/05/2023]; 93(1):28-34. Disponible en: https://doi.org/10.1016/j.jped.2016.04.006
Zhang Z, Lu B, Sheng X, Jin N. Cystatin C in prediction of acute kidney injury: A systemic review and meta-analysis.Am J Kidney Dis [Internet]. 2011 [acceso 10/05/2023]; 58(3):356-65. Disponible en: http://dx.doi.org/10.1053/j.ajkd.2011.02.389
Buhlinger KM, Fuller KA, Faircloth CB, Wallace JR. Effect of concomitant vancomycin and piperacillin-tazobactam on frequency of acute kidney injury in pediatric patients. Am J Health Syst Pharm [Internet]. 2019 [ acceso 10/05/2023];76(16):1204-10. Disponible en: https://doi.org/10.1093/ajhp/zxz125
Gabarre P, Dumas G, Dupont T, Darmon M, Azoulay E, Zafrani L. Acute kidney injury in critically ill patients with COVID-19. Intensive Care Med [Internet ]2020 [ acceso 10/05/2023 ]; 46: 1339-48. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32533197/
Stewart DJ, Hartley JC, Johnson M, Marks SD, du Pré P, Stojanovic J. Renal dysfunction in hospitalised children with COVID-19. Lancet Child Adolesc Health [ Internet ].2020 [ acceso 10/05/2023]. ;4(8):e28-e29. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295466/
Wang X, Chen X, Tang F, Luo W, Fang J, Qi C, et al. Be aware of acute kidney injury in critically ill children with COVID-19. Pediatr Nephrol. 2021 Jan;36(1):163-169. doi: 10.1007/s00467-020-04715-z. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32844290/
Kari JA, Shalaby MA, AlbannaAS, Alahmadi TS. Acute kidney injury in children with COVID-19: a retrospective study. BMC Nephrol. 2021; 22(1):202. Disponible en: https://pubmed.ncbi.nlm.nih.gov/34059010/#:~:text=Conclusions%3A%20AKI%20occurred%20in%20one,impairment%20at%20time%20of%20discharge
Hernández O. Atentos: en cualquier lugar existe riesgo de contagio con el SARS-CoV-2 [Internet]. La Habana: Centro Nacional de Información de Ciencias Médicas; 2020 [acceso 08/12/2023]. Disponible en: Disponible en: https://temas.sld.cu/SARS-CoV-2/page/5/
Manotas H, Ibarra M, Arteaga A, Romero A, Sanchez J. Lesión renal aguda en niños críticos. Acta Colombiana de Cuidado Intensivo [Internet]. 2018 [acceso 10/05/2023].18(4):207-11. Disponible en: https://doi.org/10.1016/j.acci.2018.06.003
Nadim MK, Forni LG, Mehta RL, Connor MJ Jr, et al. COVID19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup. Nat Rev Nephrol [Internet ]. 2020 [acceso 10/05/2023]; 16(12):747-64. Disponible en: https://pubmed.ncbi.nlm.nih.gov/33060844/
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